Prof. Dr. Regine Willumeit-Römer
21502 GeesthachtTel. +49 4152/87-1291E-Mail KontaktWebsite
Institut für MaterialwissenschaftKaiserstr. 2
24143 KielTel. +49 431/880-6147Website
Das Teilinstitut „Metallische Biomaterialien“ untersucht und entwickelt neue Implantatmaterialien auf Basis von Titan und Magnesium. Magnesium bietet optimale Eigenschaften für die Verwendung als resorbierbares Implantatmaterial für medizinische Anwendungen in Orthopädie, Traumatologie und Kinderheilkunde. Es hat ähnliche mechanische Eigenschaften wie der Knochen, ist ein essentielles Element für den menschlichen Körper und regt die Knochenneubildung an. Um Magnesium als Implantatmaterial auf dem Markt zu etablieren, muss zunächst unter anderem das Ausgangsmaterial untersucht werden und geprüft werden. Das Magnesium Innovations Center (MagIC) liefert das Ausgangsmaterial: die Magnesiumlegierung. Der Institutsteil „Metallische Biomaterialien“ untersucht die Faktoren, die zum Abbau des Magnesiums führen. Außerdem testen die Wissenschaftlerinnen und Wissenschaftler die Eigenschaften der Magnesium-Legierung im Laborversuch.
MIM Labor, Prozesskette vom Abguß über Extrusion und Drahtziehen und EDM zum Bauteil, Charakterisierungsmöglichkeiten: µXRF, Tomografie etc., Zellkulturlabor (Schwerpunkt humane Primärzellen, Kokulturen).
- In vivo studies of biodegradable magnesium based implant materials (MetBioMat), Virtuelles Institut der Helmholtz-Gemeinschaft
- Failure in biodegradable metal implants (Synchroload), Deutsch-Schwedischer Verbundantrag im Rahmen des Röntgen-Angstrom Cluster
- Multimodale Bildgebung zur strukturellen Analyse der Knochenmodellierung induziert durch abbaubare Magnesiumimplantate. BMBF - Förderbereich „Erforschung kondensierter Materie an Großgeräten 2016 - 2019“
• Martínez Sánchez, A.H., Omidi, M., Wurlitzer, M., Fuh, M.M., Feyerabend, F., Schlüter, H., Willumeit-Römer, R., Luthringer, B.J.C.: Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation. (2019) Bioactive Materials, 4, pp. 168-188.
• Thomsen, F., Ebel, T., Willumeit-Römer, R.: Simulation of neck growth and shrinkage for realistic temperature profiles – Determination of diffusion coefficients in a practical oriented procedure. (2019) Scripta Materialia, 168, pp. 108-113.
• Schaper, J.G., Wolff, M., Wiese, B., Ebel, T., Willumeit-Römer, R.: Powder metal injection moulding and heat treatment of AZ81 Mg alloy. (2019) Journal of Materials Processing Technology, 267, pp. 241-246.
• Willumeit-Römer, R.: The Interface Between Degradable Mg and Tissue. (2019) JOM, 71 (4), pp. 1447-1455.
• Reddy Tiyyagura, H., Petovar, B., Finšgar, M., Willumeit-Römer, R., Luthringer, B.J.C., Mohan, M.K., Kokol, V.: Degradation behaviour of Mg-4Ag and Mg-5Gd alloys under in-vitro conditions and different time-frames. (2019) Journal of Alloys and Compounds, 774, pp. 980-987.
• Helmholz, H., Luthringer-Feyerabend, B.J.C., Willumeit-Römer, R.: Elemental mapping of biodegradable magnesium-based implants in bone and soft tissue by means of μ X-ray fluorescence analysis. (2019) Journal of Analytical Atomic Spectrometry, 34 (2), pp. 356-365.
• Mei, D., Lamaka, S.V., Gonzalez, J., Feyerabend, F., Willumeit-Römer, R., Zheludkevich, M.L.: The role of individual components of simulated body fluid on the corrosion behavior of commercially pure Mg. (2019) Corrosion Science, 147, pp. 81-93.
• Gawlik, M.M., Wiese, B., Welle, A., González, J., Desharnais, V., Harmuth, J., Ebel, T., Willumeit-Römer, R.: Acetic acid etching of Mg-xGd alloys. (2019) Metals, 9 (2), art. no. 117, .
• Xu, L., Willumeit-Römer, R., Luthringer-Feyerabend, B.J.C.: Effect of magnesium-degradation products and hypoxia on the angiogenesis of human umbilical vein endothelial cells. (2019) Acta Biomaterialia, .
• Hou, R.-Q., Scharnagl, N., Willumeit-Römer, R., Feyerabend, F.: Different effects of single protein vs. protein mixtures on magnesium degradation under cell culture conditions. (2019) Acta Biomaterialia, .
• Wolff, M., Mesterknecht, T., Bals, A., Ebel, T., Willumeit-Römer, R.: FFF of Mg-Alloys for Biomedical Application. (2019) Minerals, Metals and Materials Series, pp. 43-49.
• Anisimova, N., Kiselevskiy, M., Martynenko, N., Straumal, B., Willumeit-Römer, R., Dobatkin, S., Estrin, Y.: Cytotoxicity of biodegradable magnesium alloy WE43 to tumor cells in vitro: Bioresorbable implants with antitumor activity? (2019) Journal of Biomedical Materials Research - Part B Applied Biomaterials, .
• Gawlik, M.M., Wiese, B., Desharnais, V., Ebel, T., Willumeit-Römer, R.: The effect of surface treatments on the degradation of biomedical Mg alloys-a review paper. (2018) Materials, 11 (12), art. no. 2561, .
• Hou, R., Willumeit-Römer, R., Garamus, V.M., Frant, M., Koll, J., Feyerabend, F.: Adsorption of Proteins on Degradable Magnesium - Which Factors are Relevant? (2018) ACS Applied Materials and Interfaces, 10 (49), pp. 42175-42185.
• Thomsen, F., Hofmann, G., Ebel, T., Willumeit-Römer, R.: An elementary simulation model for neck growth and shrinkage during solid phase sintering. (2018) Materialia, 3, pp. 338-346.
• Schaper, J.G., Scharnagl, N., Wolff, M., Ebel, T., Neumann, S., Willumeit-Römer, R.: Polyolefin-Magnesium Interactions Performing Powder Injection Molding Process. (2018) Advanced Engineering Materials, 20 (11), art. no. 1800530, .
• Jia, G., Chen, C., Zhang, J., Wang, Y., Yue, R., Luthringer - Feyerabend, B.J.C., Willumeit-Roemer, R., Zhang, H., Xiong, M., Huang, H., Yuan, G., Feyerabend, F.: In vitro degradation behavior of Mg scaffolds with three-dimensional interconnected porous structures for bone tissue engineering. (2018) Corrosion Science, 144, pp. 301-312.
• Agha, N.A., Liu, Z., Feyerabend, F., Willumeit-Römer, R., Gasharova, B., Heidrich, S., Mihailova, B.: The effect of osteoblasts on the surface oxidation processes of biodegradable Mg and Mg-Ag alloys studied by synchrotron IR microspectroscopy. (2018) Materials Science and Engineering C, 91, pp. 659-668.
• Lamaka, S.V., Gonzalez, J., Mei, D., Feyerabend, F., Willumeit-Römer, R., Zheludkevich, M.L.: Local pH and Its Evolution Near Mg Alloy Surfaces Exposed to Simulated Body Fluids. (2018) Advanced Materials Interfaces, 5 (18), art. no. 1800169, .
• Wolff, M., Luczak, M., Schaper, J.G., Wiese, B., Dahms, M., Ebel, T., Willumeit-Römer, R., Klassen, T.: In vitro biodegradation testing of Mg-alloy EZK400 and manufacturing of implant prototypes using PM (powder metallurgy) methods. (2018) Bioactive Materials, 3 (3), pp. 213-217.
• ZHAO, D.-P., CHEN, Y.-K., CHANG, K.-K., EBEL, T., LUTHRIGNER-FEYERABEND, B.J.C., WILLUMEIT-RÖMER, R., PYCZAK, F.: Surface topography and cytocompatibility of metal injection molded Ti–22Nb alloy as biomaterial. (2018) Transactions of Nonferrous Metals Society of China (English Edition), 28 (7), pp. 1342-1350.
• Okulov, I.V., Okulov, A.V., Soldatov, I.V., Luthringer, B., Willumeit-Römer, R., Wada, T., Kato, H., Weissmüller, J., Markmann, J.: Open porous dealloying-based biomaterials as a novel biomaterial platform. (2018) Materials Science and Engineering C, 88, pp. 95-103.
• Gonzalez, J., Hou, R.Q., Nidadavolu, E.P.S., Willumeit-Römer, R., Feyerabend, F.: Magnesium degradation under physiological conditions – Best practice. (2018) Bioactive Materials, 3 (2), pp. 174-185.
• Hou, R.-Q., Scharnagl, N., Feyerabend, F., Willumeit-Römer, R.: Exploring the effects of organic molecules on the degradation of magnesium under cell culture conditions. (2018) Corrosion Science, 132, pp. 35-45.
• Zeller-Plumhoff, B., Helmholz, H., Feyerabend, F., Dose, T., Wilde, F., Hipp, A., Beckmann, F., Willumeit-Römer, R., Hammel, J.U.: Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time-lapse SRµCT. (2018) Materials and Corrosion, 69 (3), pp. 298-306.
• Dahms, M., Höche, D., Ahmad Agha, N., Feyerabend, F., Willumeit-Römer, R.: A simple model for long-time degradation of magnesium under physiological conditions. (2018) Materials and Corrosion, 69 (2), pp. 191-196.
• Willumeit-Römer, R., Ahmad Agha, N., Luthringer, B.: Degradable magnesium implants—assessment of the current situation. (2018) Minerals, Metals and Materials Series, Part F7, pp. 405-411.
• Lu, Y., Huang, Y., Feyerabend, F., Willumeit-Römer, R., Kainer, K.U., Hort, N.: Microstructure and mechanical properties of mg-gd alloys as biodegradable implant materials. (2018) Minerals, Metals and Materials Series, Part F12, pp. 253-262.
• Wolff, M., Schaper, J.G., Dahms, M., Ebel, T., Willumeit-Römer, R., Klassen, T.: Metal injection molding (MIM) of mg-alloys. (2018) Minerals, Metals and Materials Series, Part F12, pp. 239-251.
• Amaya Moreno, L., Omidi, M., Wurlitzer, M., Luthringer, B., Helmholz, H., Schluter, H., Willumeit-Romer, R., Fugenschuh, A.: Understanding Protein Networks using Vester’s Sensitivity Model. (2018) IEEE/ACM Transactions on Computational Biology and Bioinformatics, . Article in Press.
• Willumeit-Römer, R., Moosmann, J., Zeller-Plumhoff, B., Florian Wieland, D.C., Krüger, D., Wiese, B., Wennerberg, A., Peruzzi, N., Galli, S., Beckmann, F., Hammel, J.U.: Visualization of implant failure by synchrotron tomography. (2018) Minerals, Metals and Materials Series, Part F12, pp. 275-284.
• Wu, L., Luthringer, B.J.C., Feyerabend, F., Zhang, Z., Machens, H.G., Maeda, M., Taipaleenmäki, H., Hesse, E., Willumeit-Römer, R., Schilling, A.F.: Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men. (2017) Osteoporosis International, 28 (11), pp. 3215-3228.
• Bonyadi Rad, E., Mostofi, S., Katschnig, M., Schmutz, P., Pawelkiewicz, M., Willumeit-Römer, R., Schäfer, U., Weinberg, A.: Differential apoptotic response of MC3T3-E1 pre-osteoblasts to biodegradable magnesium alloys in an in vitro direct culture model. (2017) Journal of Materials Science: Materials in Medicine, 28 (10), art. no. 155, .
• Zou, A., Zhao, X., Handge, U.A., Garamus, V.M., Willumeit-Römer, R., Yin, P.: Folate receptor targeted bufalin/β-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin. (2017) Materials Science and Engineering C, 78, pp. 609-618.
• Liu, Z., Schade, R., Luthringer, B., Hort, N., Rothe, H., Müller, S., Liefeith, K., Willumeit-Römer, R., Feyerabend, F.: Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys in Vitro. (2017) Oxidative Medicine and Cellular Longevity, 2017, art. no. 8091265, .
• Yang, L., Ma, L., Huang, Y., Feyerabend, F., Blawert, C., Höche, D., Willumeit-Römer, R., Zhang, E., Kainer, K.U., Hort, N.: Influence of Dy in solid solution on the degradation behavior of binary Mg-Dy alloys in cell culture medium. (2017) Materials Science and Engineering C, 75, pp. 1351-1358.
• Wieland, D.C.F., Zander, T., Garamus, V.M., Krywka, C., Dedinaite, A., Claesson, P., Willumeit-Römer, R.: Complex solutions under shear and pressure: A rheometer setup for X-ray scattering experiments. (2017) Journal of Synchrotron Radiation, 24 (3), pp. 646-652.
• Zaatreh, S., Haffner, D., Strauß, M., Wegner, K., Warkentin, M., Lurtz, C., Zamponi, C., Mittelmeier, W., Kreikemeyer, B., Willumeit-Römer, R., Quandt, E., Bader, R.: Fast corroding, thin magnesium coating displays antibacterial effects and low cytotoxicity. (2017) Biofouling, 33 (4), pp. 294-305.
• Mohedano, M., Luthringer, B.J.C., Mingo, B., Feyerabend, F., Arrabal, R., Sanchez-Egido, P.J., Blawert, C., Willumeit-Römer, R., Zheludkevich, M.L., Matykina, E.: Bioactive plasma electrolytic oxidation coatings on Mg-Ca alloy to control degradation behaviour. (2017) Surface and Coatings Technology, 315, pp. 454-467.
• Martinez Sanchez, A.H., Feyerabend, F., Laipple, D., Willumeit-Römer, R., Weinberg, A., Luthringer, B.J.C.: Chondrogenic differentiation of ATDC5-cells under the influence of Mg and Mg alloy degradation. (2017) Materials Science and Engineering C, 72, pp. 378-388.
• Raj, A., Wang, M., Zander, T., Wieland, D.C.F., Liu, X., An, J., Garamus, V.M., Willumeit-Römer, R., Fielden, M., Claesson, P.M., Dėdinaitė, A.: Lubrication synergy: Mixture of hyaluronan and dipalmitoylphosphatidylcholine (DPPC) vesicles. (2017) Journal of Colloid and Interface Science, 488, pp. 225-233.
• Myrissa, A., Braeuer, S., Martinelli, E., Willumeit-Römer, R., Goessler, W., Weinberg, A.M.: Gadolinium accumulation in organs of Sprague–Dawley® rats after implantation of a biodegradable magnesium-gadolinium alloy. (2017) Acta Biomaterialia, 48, pp. 521-529.
• Burmester, A., Willumeit-Römer, R., Feyerabend, F.: Behavior of bone cells in contact with magnesium implant material. (2017) Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105 (1), pp. 165-179.
• Zhen, Z., Luthringer, B., Yang, L., Xi, T., Zheng, Y., Feyerabend, F., Willumeit, R., Lai, C., Ge, Z.: Proteomic profile of mouse fibroblasts exposed to pure magnesium extract. (2016) Materials Science and Engineering C, 69, pp. 522-531.
• Jin, L., Garamus, V.M., Liu, F., Xiao, J., Eckerlebe, H., Willumeit-Römer, R., Mu, B., Zou, A.: Interaction of a biosurfactant, Surfactin with a cationic Gemini surfactant in aqueous solution. (2016) Journal of Colloid and Interface Science, 481, pp. 201-209.
• Zhao, S., Minh, L.V., Li, N., Garamus, V.M., Handge, U.A., Liu, J., Zhang, R., Willumeit-Römer, R., Zou, A.: Doxorubicin hydrochloride-oleic acid conjugate loaded nanostructured lipid carriers for tumor specific drug release. (2016) Colloids and Surfaces B: Biointerfaces, 145, pp. 95-103.
• Agha, N.A., Willumeit-Römer, R., Laipple, D., Luthringer, B., Feyerabend, F.: The degradation interface of magnesium based alloys in direct contact with human primary osteoblast cells. (2016) PLoS ONE, 11 (6), art. no. e0157874.
• Wolff, M., Schaper, J.G., Suckert, M.R., Dahms, M., Feyerabend, F., Ebel, T., Willumeit-Römer, R., Klassen, T.: Metal injection molding (MIM) of magnesium and its alloys. (2016) Metals, 6 (5), art. no. 118.
• Marco, I., Feyerabend, F., Willumeit-Römer, R., Van Der Biest, O.: Degradation testing of Mg alloys in Dulbecco's modified eagle medium: Influence of medium sterilization. (2016) Materials Science and Engineering C, 62, pp. 68-78.
• Jähn, K., Saito, H., Taipaleenmäki, H., Gasser, A., Hort, N., Feyerabend, F., Schlüter, H., Rueger, J.M., Lehmann, W., Willumeit-Römer, R., Hesse, E.: Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice. (2016) Acta Biomaterialia, 36, pp. 350-360.
• Wolff, M., Schaper, J.G., Suckert, M.R., Dahms, M., Ebel, T., Willumeit-Römer, R., Klassen, T.: Magnesium Powder Injection Molding (MIM) of Orthopedic Implants for Biomedical Applications. (2016) JOM, 68 (4), pp. 1191-1197.
• Chen, Y., Van Minh, L., Liu, J., Angelov, B., Drechsler, M., Garamus, V.M., Willumeit-Römer, R., Zou, A.: Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting. (2016) Colloids and Surfaces B: Biointerfaces, 140, pp. 74-82.
• Myrissa, A., Agha, N.A., Lu, Y., Martinelli, E., Eichler, J., Szakács, G., Kleinhans, C., Willumeit-Römer, R., Schäfer, U., Weinberg, A.-M.: In vitro and in vivo comparison of binary Mg alloys and pure Mg. (2016) Materials Science and Engineering C, 61, pp. 865-874.
• Deing, A., Ebel, T., Willumeit-Römer, R., Luthringer, B.J.C.: Comparison of the influence of phospholipid-coated porous Ti-6Al-4V material on the osteosarcoma cell line Saos-2 and primary human bone derived cells. (2016) Metals, 6 (3), art. no. 66.
• Golub, M., Lott, D., Garamus, V.M., Laipple, D., Stoermer, M., Watkins, E.B., Schreyer, A., Willumeit-Römer, R.: Neutron study of phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine spray coating on titanium implants. (2016) Biointerphases, 11 (1), p. 011002.
• Luthringer, B.J.C., Willumeit-Römer, R.: Effects of magnesium degradation products on mesenchymal stem cell fate and osteoblastogenesis. (2016) Gene, 575 (1), pp. 9-20.
• Lu, Y., Huang, Y., Feyerabend, F., Willumeit-Römer, R., Kainer, K.U., Hort, N.: In vitro corrosion and cytocompatibility properties of Mg-2Gd-X(Ag, Ca) alloys. (2016) Magnesium Technology, 2016-January, pp. 347-351.
• Agha, N.A., Feyerabend, F., Mihailova, B., Heidrich, S., Bismayer, U., Willumeit-Römer, R.: Magnesium degradation influenced by buffering salts in concentrations typical of in vitro and in vivo models. (2016) Materials Science and Engineering C, 58, art. no. 5779, pp. 817-825.
• Wieland, D.C.F., Degen, P., Zander, T., Gayer, S., Raj, A., An, J., Dedinaite, A., Claesson, P., Willumeit-Römer, R.: Structure of DPPC-hyaluronan interfacial layers-effects of molecular weight and ion composition. (2016) Soft Matter, 12 (3), pp. 729-740.
• Golub, M., Lott, D., Garamus, V.M., Laipple, D., Stoermer, M., Watkins, E.B., Schreyer, A., Willumeit-Römer, R.: Neutron study of phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine spray coating on titanium implants. (2016) Biointerphases, 11 (1), pp. 1-8.
• Cecchinato, F., Agha, N.A., Martinez-Sanchez, A.H., Luthringer, B.J.C., Feyerabend, F., Jimbo, R., Willumeit-Römer, R., Wennerberg, A.: Influence of magnesium alloy degradation on undifferentiated human cells. (2015) PLoS ONE, 10 (11), art. no. e0142117.
• Chen, Y., Angelova, A., Angelov, B., Drechsler, M., Garamus, V.M., Willumeit-Römer, R., Zou, A.: Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines.
(2015) Journal of Materials Chemistry B, 3 (39), pp. 7734-7744.
• Wang, M., Zander, T., Liu, X., Liu, C., Raj, A., Florian Wieland, D.C., Garamus, V.M., Willumeit-Römer, R., Claesson, P.M., Dedinaite, A.: The effect of temperature on supported dipalmitoylphosphatidylcholine (DPPC) bilayers: Structure and lubrication performance. (2015) Journal of Colloid and Interface Science, 445, pp. 84-92.
• Wieland, D.C.F., Krywka, C., Mick, E., Willumeit-Römer, R., Bader, R., Kluess, D.: Investigation of the inverse piezoelectric effect of trabecular bone on a micrometer lengthscale using synchrotron radiation. (2015) Acta Biomaterialia, Article in Press.
• Feyerabend, F., Wendel, H.-P., Mihailova, B., Heidrich, S., Agha, N.A., Bismayer, U., Willumeit-Römer, R.: Blood compatibility of magnesium and its alloys. (2015) Acta Biomaterialia, Article in Press.
• Marco, I., Feyerabend, F., Willumeit-Römer, R., Van Der Biest, O.: Influence of testing environment on the degradation behavior of magnesium alloys for bioabsorbable implants. (2015)
TMS Annual Meeting, 2015-March, pp. 499-506.
• Zhao, D., Chang, K., Ebel, T., Nie, H., Willumeit, R., Pyczak, F.: Sintering behavior and mechanical properties of a metal injection molded Ti-Nb binary alloy as biomaterial. (2015) Journal of Alloys and Compounds, 640, pp. 393-400.
• Shi, L.-L., Huang, Y., Yang, L., Feyerabend, F., Mendis, C., Willumeit, R., Ulrich Kainer, K., Hort, N.: Mechanical properties and corrosion behavior of Mg-Gd-Ca-Zr alloys for medical applications. (2015) Journal of the Mechanical Behavior of Biomedical Materials, 47, pp. 38-48.
• Ciobanasu, C., Rzeszutek, A., Kubitscheck, U., Willumeit, R.: NKCS, a mutant of the NK-2 peptide, causes severe distortions and perforations in bacterial, but not human model lipid membranes. (2015) Molecules, 20 (4), pp. 6941-6958.
• Sanchez, A.H.M., Luthringer, B.J.C., Feyerabend, F., Willumeit, R.: Mg and Mg alloys: How comparable are in vitro and in vivo corrosion rates? A review. (2015) Acta Biomaterialia, 13, pp. 16-31.